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3/) %4 <br /> Technology Overview <br /> GalaGen's technology platform enables it to produce large quantities of pathogen-specific antibodies in the <br /> milk of dairy cows. Antibodies are infection-fighting proteins produced by lymphocytes,or white blood cells, <br /> and are directed against a wide array of pathogens that the body encounters throughout its life. While <br /> antibodies circulate in the bloodstream, they also are found in other body fluids, including milk, saliva and <br /> other secretions. Antibodies are normal constituents of milk, yogurt and other dairy foods; however, the <br /> pasteurization process inactivates most antibodies so they are either not functional in dairy foods or are <br /> present in quantities too low be effective. GalaGen's proprietary technology produces far more antibodies <br /> than are available in standard dairy foods, especially antibodies that are directed against specific human <br /> diseases, and preserves their biologic activity. There are three major components of this technology: <br /> Antibody-rich colostrum as a raw material. <br /> GalaGen uses the first milk produced during a cow's lactation, called colostrum, that is well tolerated <br /> and much richer in antibodies than milk produced later in lactation. The mother cow transfers <br /> antibodies into the colostrum from the bloodstream just prior to birth of the calf.These antibodies, <br /> active against a range of infections encountered by the mother during her lifetime, provide the initial <br /> critical line of defense for the calf during the first month of life. <br /> Immunization technology. <br /> GalaGen's proprietary technology enhances the cow's natural production of antibodies by <br /> immunizing the cow against human pathogens. The components of GalaGen's immunization <br /> regimens are proprietary and have been demonstrated to yield high levels of antibodies that attack the <br /> specific human pathogen of interest. These antibodies are transferred into the colostrum. <br /> Manufacturing technology. <br /> GalaGen uses proprietary production methods to concentrate the colostrum very gently so that <br /> maximal antibody activity is preserved. The resulting concentrate is dried to a stable powder that is <br /> similar in appearance to non-fat dried skim milk. <br /> II <br />�II <br /> r <br />