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The BMA has noted literature finding electronic cigarettes as safer than tobacco smoking, but <br /> also is concerned by the lack of high quality peer- reviewed studies about safety. They have noted <br /> that the amount of nicotine delivered can be highly variable between devices due to differences <br /> in how well the nicotine is vaporized. They have also raised concerns that the delivered dose <br /> may be inconsistent or misleading compared to the nicotine level stated on the liquid container, <br /> with identically labelled cartridges emitting "markedly different" levels of nicotine. Issues <br /> around proper labeling, child -proof packaging, and electrical safety have also been raised .L <br /> A preliminary analysis of e- cigarette cartridges by the US Food and Drug Administration (FDA) <br /> in 2009 identified that some contain tobacco - specific nitrosamines (TSNAs), known cancer - <br /> causing agents. r 151[161 The amounts of TSNAs present were on par with existing NRT products <br /> like nicotine gum and inhalers. The FDA's analysis also detected diethylene glycol, a poisonous <br /> and hygroscopic liquid, in a single cartridge manufactured by Smoking Everywhere and nicotine <br /> in oneU G <br /> cartridge claimed to be nicotine -free. Diethylene glycol was found in a cartridge <br /> tested in 2009 by the FDA, but in 2011 researchers reviewed the data and noted that 15 other <br /> studies had failed to find any evidence of this chemical in e- cigarettes. Further concerns were <br /> raised over inconsistent amounts of nicotine delivered when drawing on the device. In some e- <br /> cigarettes, "Tobacco- specific impurities suspected of being harmful to humans — anabasine, <br /> myosmine, and 0- nicotyrine — were detected in a majority of the samples tested." It is not clear if <br /> these chemicals were detectable in exhaled vapor. 19 The UK National Health Service noted that <br /> the toxic chemicals found by the FDA were at levels one - thousandth that of cigarette smoke, and <br /> that while there is no certainty that these small traces are harmless, initial test results are <br /> reassuring. <br /> 20 <br /> Addiction <br /> A number of organizations including the Centers for Disease Control and Prevention, the <br /> International Union Against Tuberculosis and Lung Disease, the American Academy of <br /> Pediatrics [22) and the Food and Drug Administration have concerns that a -cigs might increase <br /> addiction to and use of nicotine and tobacco products in children. [241[251 The World Health <br /> Organization raises the concern of addiction from their use. 26 A 2013 report by the CDC <br /> analysing the 2012 National Youth Tobacco Survey (NYTS), a survey including 24,658 US <br /> students, found that while electronic cigarette use among middle and high school students almost <br /> doubled from 2011 to 2012, use of certain tobacco products (bidis and krekets) were shown to <br /> have fallen over the same period. <br /> Usage <br /> Electronic cigarette sales increased from 50,000 in 2008 to 3.5 million in 2012. As of 2011, in <br /> the United States, one in five adults who smoke have tried electronic cigarettes. 39 In a UK <br /> survey conducted in 2013 of more than 12,000 adults, 11% of regular smokers in the sample <br /> identified themselves as using electronic cigarettes and 24% stated that they had used them in the <br /> past. Amongst non - smokers in the same sample, 1 % said they had tried them and 0% stated that <br /> they were currently using them. [401 <br /> 19 <br />